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tautomycin
From Streptomyces spiroverticillatus. Inhibits PP1 (IC50=1nM), PP2A (IC50=10nM), smooth muscle endogenous phosphatase (IC50=6nM). Does not inhibit PP2C, myosin light chain kinase.
General
phosphatase inhibitor
prokaryote-specific molecule
Properties
SIZE: MW = 767 G/MOL
INHIBITS: phosphatase-1
phosphatase-2A
Database Correlations
PUBCHEM correlations
References
Calbiochem flyer:
Suganuma et al Toxicon 30:873 1992
Gong et al J Biol Chem 267:14662 1992
MacKintosh & Klumpp FEBS Lett 277:137 1990
Magae et al J Antibiot 42:1290 1989