Tat-SF complex

Structure: - consists of: HTATSF1, CDK9, CCNT1, SUPT5H, nucleolin

General

molecular complex nuclear protein

Properties

COMPARTMENT: cell nucleus SUBUNITS: HIV Tat-specific factor 1 COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 133-218 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif lysine-rich region {228-234} MOTIF: lysine residue (SEVERAL) RNP motif NAME: RNP motif SITE: 264-349 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Mediates interaction with the P-TEFb complex. {381-755} MOTIF: acidic region {423-754} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S624} Ser phosphorylation site {S642} Ser phosphorylation site {S702} cyclin-dependent kinase-9 (CDK9) STATE: active state MOTIF: kinase domain SITE: 19-315 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 25-33 ATP-binding site NAME: ATP-binding site SITE: 48-48 aspartate residue {D149} Thr phosphorylation site {T186} cyclin T1 COMPARTMENT: cell nucleus CELL-CYCLE: G1 MOTIF: cyclin box FOR-BINDING-OF: cyclin-dependent kinase coiled coil {379-430} PEST region SITE: 709-726 transcription elongation factor SPT5 COMPARTMENT: cell nucleus MOTIF: glutamate-rich region {11-106} MOTIF: glutamate residue (SEVERAL) binding site SITE: 176-270 FOR-BINDING-OF: transcription elongation factor SPT4 KOW 1 {273-306} RNA pol-2 interaction {313-420} KOW 2 {420-451} KOW 3 {472-503} KOW 4 {594-627} Ser phosphorylation site {S666} KOW 5 {704-737} MOTIF: Thr phosphorylation site {T709} Tyr phosphorylation site {Y717} CTR1 {754-817} MOTIF: G- S-[QR]-T-P-X-[YQ] {754-817} (9) Thr phosphorylation site {T775} Thr phosphorylation site {T784} CTR2 NAME: CTR2 SITE: 844-968 MOTIF: proline residue (SEVERAL) P-[TS]-P-S-P-[QA]-[SG]-Y (10) Thr phosphorylation site {T1034} nucleolin MOTIF: Ser phosphorylation site {S28} Ser phosphorylation site {S34} Ser phosphorylation site {S41} Ser phosphorylation site {S42} 8 X 8 AA tandem repeats of X-T-P-X-K-K-X- X {58-135} MOTIF: consensus repeat {58-65} Ser phosphorylation site {S67} Thr phosphorylation site {T69} consensus repeat {75-82} Thr phosphorylation site {T76} consensus repeat {83-90} consensus repeat {91-98} consensus repeat {99-104} Thr phosphorylation site {T99} consensus repeat {105-112} Thr phosphorylation site {T105} consensus repeat {120-127} Thr phosphorylation site {T121} consensus repeat {128-135} acidic region {143-171} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S145} Ser phosphorylation site {S153} Ser phosphorylation site {S184} acidic region {185-209} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S206} Thr phosphorylation site {T214} acidic region {234-271} MOTIF: acidic residue (SEVERAL) RNP motif NAME: RNP motif SITE: 307-383 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Thr phosphorylation site {T367} RNP motif NAME: RNP motif SITE: 393-466 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 486-560 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S563} RNP motif NAME: RNP motif SITE: 572-647 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S580} Ser phosphorylation site {S619} RNA polymerase-2

References

UniProt :accession O43719

Components

cyclin T1 (CCNT1) cyclin-dependent kinase-9 (CDK9, serine/threonine protein kinase PITALRE, CDC2L4) HIV Tat-specific factor 1 (HTATSF1, Tat-SF1) nucleolin; protein C23 (NCL) RNA polymerase-2 transcription elongation factor SPT5; hSPT5; DRB sensitivity-inducing factor large subunit; DSIF large subunit; DSIF p160; Tat-cotransactivator 1 protein; Tat-CT1 protein (SUPT5H, SPT5, SPT5H)