TAT-binding protein-1; 26S protease regulatory subunit 6A; proteasome subunit P50 (TBP1, PSMC3)

Function: - regulatory ATPase of 26S proteasome - confers ATP dependency & substrate specificity to the 26S proteasome - may form a heterodimer with a related family member - interacts with PAAF1 - interacts with HIV-1 Tat, suppresses Tat-mediated transactivation Structure: belongs to the AAA ATPase family Compartment: cytoplasm, nucleus

General

adenosine triphosphatase (ATPase) phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 439 aa MW = 49 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S9} ATP-binding site NAME: ATP-binding site SITE: 227-234

Database Correlations

OMIM 186852 UniProt P17980 Pfam PF00004 Kegg hsa:5702

References

UniProt :accession P17980