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taste receptor type 2 member 42 (T2R42, T2R55, TAS2R42, TAS2R55)
Function:
- receptor may play a role in the perception of bitterness
- gustducin-linked
- role in sensing chemical composition of gastrointestinal content
- activity of TAS2R42 may stimulate alpha gustducin, mediate PLC-beta-2 activation & lead to the gating of TRPM5
Structure: belongs to the G-protein coupled receptor T2R family
Compartment: membrane; Multi-pass membrane protein
General
glycoprotein
taste receptor, type 2
Properties
SIZE: MW = 36 kD
entity length = 314 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-7}
transmembrane domain {8-28}
cytoplasmic loop {29-50}
transmembrane domain {51-71}
exoplasmic loop {72-101}
transmembrane domain {102-122}
cytoplasmic loop {123-127}
transmembrane domain {128-148}
exoplasmic loop {149-187}
MOTIF: N-glycosylation site {N163}
transmembrane domain {188-208}
cytoplasmic loop {209-238}
transmembrane domain {239-259}
exoplasmic loop {260-265}
transmembrane domain {266-286}
cytoplasmic domain {287-314}
Database Correlations
UniProt Q7RTR8
Pfam PF05296
Entrez Gene 259288
Kegg hsa:3531
References
UniProt :accession Q7RTR8