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taste receptor, type 1, member 1 (G-protein coupled receptor 70, Gm148, TAS1R1, GPR70, T1R1, TR1)
Function:
1) taste receptor (putative)
2) TAS1R1/TAS1R3 responds to the umami taste stimulus (taste of monosodium glutamate, MSG)
3) forms heterodimers with TAS1R3
Structure:
- belongs to the G-protein coupled receptor 3 family TAS1R subfamily
Compartment: cell membrane
Alternative splicing: named isoforms=4
General
glycoprotein
taste receptor, type 1
Properties
SIZE: MW = 93 kD
entity length = 841 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
exoplasmic domain {21-567}
MOTIF: N-glycosylation site {N87}
N-glycosylation site {N88}
N-glycosylation site {N95}
N-glycosylation site {N291}
N-glycosylation site {N479}
N-glycosylation site {N529}
transmembrane domain {568-588}
cytoplasmic loop {589-603}
transmembrane domain {604-624}
exoplasmic loop {625-639}
transmembrane domain {640-660}
cytoplasmic loop {661-680}
transmembrane domain {681-701}
exoplasmic loop {702-725}
transmembrane domain {726-746}
cytoplasmic loop {747-761}
transmembrane domain {762-782}
exoplasmic loop {783-795}
transmembrane domain {796-816}
cytoplasmic domain {817-841}
Database Correlations
OMIM 606225
UniProt Q7RTX1
PFAM correlations
Entrez Gene 80835
Kegg hsa:8083
References
- UniProt :accession Q7RTX1
- Protein Spotlight; Note: The taste experience -
Issue 55 of February 2005
http://www.expasy.org/spotlight/back_issues/sptlt055.shtml