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targeting protein for Xklp2 (restricted expression proliferation-associated protein 100, p100, differentially expressed in cancerous & noncancerous lung cells 2, DIL-2, protein FLS353, hepatocellular carcinoma-associated antigen 519, TPX2, C20orf1, C20orf2, DIL2, HCA519)
Compartment:
- nucleus
- during mitosis, strictly associated with the spindle pole & with the mitotic spindle
- during S & G2, it is diffusely distributed throughout nucleus
Expression:
- exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis
Pathology:
- expressed in lung carcinoma cell lines but not in normal lung tissues
General
nuclear protein
phosphoprotein
Properties
SIZE: MW = 86 kD
entity length = 747 aa
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T51}
Thr phosphorylation site {T72}
Ser phosphorylation site {S121}
Ser phosphorylation site {S125}
Thr phosphorylation site {T147}
Ser phosphorylation site {S186}
Ser phosphorylation site {S293}
Thr phosphorylation site {T338}
Ser phosphorylation site {S359}
Thr phosphorylation site {T369}
Thr phosphorylation site {T374}
Ser phosphorylation site {S486}
Ser phosphorylation site {S542}
Ser phosphorylation site {S652}
Ser phosphorylation site {S654}
Ser phosphorylation site {S738}
Database Correlations
OMIM 605917
UniProt Q9ULW0
Pfam PF06886
References
UniProt :accession Q9ULW0