182 kD tankyrase-1-binding protein (TNKS1BP1, KIAA1741, TAB182)

Function: - ADP-ribosylated by TNKS1 (in vitro) - phosphorylated upon DNA damage, probably by ATM or ATR - binds to the ANK repeat domain of TNKS1 & TNKS2 Compartment: - nucleus, cytoplasm, cytoskeleton, chromosome - colocalizes with chromosomes during mitosis, & in the cytoplasm with cortical actin Alternative splicing: named isoforms=2 Expression: - expressed in testis, ovary, lung, skeletal muscle, heart, prostate & pancreas - expressed at very low levels in brain & peripheral blood leukocytes

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 1729 aa MW = 182 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: proline-rich region SITE: 2-103 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 127-767 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S178} Acidic {210-1572} MOTIF: Ser phosphorylation site {S221} Ser phosphorylation site {S228} Thr phosphorylation site {T239} Ser phosphorylation site {S287} Ser phosphorylation site {S301} Ser phosphorylation site {S429} Ser phosphorylation site {S435} Ser phosphorylation site {S437} Ser phosphorylation site {S494} Ser phosphorylation site {S498} Ser phosphorylation site {S504} Ser phosphorylation site {S518} Ser phosphorylation site {S601} Ser phosphorylation site {S672} Ser phosphorylation site {S691} Ser phosphorylation site {S695} Ser phosphorylation site {S712} Ser phosphorylation site {S714} Ser phosphorylation site {S744} Ser phosphorylation site {S762} Ser phosphorylation site {S806} Thr phosphorylation site {T833} Ser phosphorylation site {S836} Ser phosphorylation site {S872} Ser phosphorylation site {S893} Ser phosphorylation site {S920} Ser phosphorylation site {S936} Ser phosphorylation site {S976} Thr phosphorylation site {T979} Ser phosphorylation site {S983} Ser phosphorylation site {S987} Ser phosphorylation site {S1008} glycine-rich region {1010-1340} Ser phosphorylation site {S1024} Ser phosphorylation site {S1029} Ser phosphorylation site {S1093} Ser phosphorylation site {S1103} Ser phosphorylation site {S1133} Ser phosphorylation site {S1138} Ser phosphorylation site {S1141} Ser phosphorylation site {S1178} Ser phosphorylation site {S1181} Ser phosphorylation site {S1248} Thr phosphorylation site {T1282} Ser phosphorylation site {S1297} Ser phosphorylation site {S1328} Ser phosphorylation site {S1331} Ser phosphorylation site {S1383} Ser phosphorylation site {S1385} Ser phosphorylation site {S1405} Ser phosphorylation site {S1439} binding site SITE: 1450-1542 FOR-BINDING-OF: tankyrase Ser phosphorylation site {S1452} Ser phosphorylation site {S1473} Ser phosphorylation site {S1476} Ser phosphorylation site {S1533} Ser phosphorylation site {S1545} Ser phosphorylation site {S1552} Ser phosphorylation site {S1554} Ser phosphorylation site {S1558} Thr phosphorylation site {T1563} lysine-rich region {1572-1729} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S1616} Ser phosphorylation site {S1620} Ser phosphorylation site {S1621} nuclear translocation signal {1629-1635} Ser phosphorylation site {S1652} Ser phosphorylation site {S1654} Ser phosphorylation site {S1666} Ser phosphorylation site {S1715} nuclear translocation signal {1723-1729}

Database Correlations

OMIM 607104 UniProt Q9C0C2 Entrez Gene 85456 Kegg hsa:85456

References

UniProt :accession Q9C0C2