Search
talin-2 (TLN2, KIAA0320)
Function:
- component of focal adhesion plaques
- links integrin to the actin cytoskeleton
- role in cell adhesion
- recruits PIP5K1C to focal adhesion plaques, activates its kinase activity
Structure:
- contains 1 FERM domain
- contains 1 I/LWEQ domain
Compartment: cell junction, focal adhesion, synapse
Related
talin-1 (TLN1, KIAA1027, TLN)
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: MW = 272 kD
entity length = 2542 aa
COMPARTMENT: cytoplasm
MOTIF: FERM domain
NAME: FERM domain
SITE: 88-406
MOTIF: interaction with PIP5K1C {312-406}
alanine-rich region {861-1193}
MOTIF: alanine residue (SEVERAL)
Thr phosphorylation site {T1843}
I/LWEQ {2294-2533}
Database Correlations
OMIM 607349
UniProt Q9Y4G6
PFAM correlations
References
UniProt :accession Q9Y4G6