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talin-1 (TLN1, KIAA1027, TLN)
Function:
- role in connections of major cytoskeletal structures to the plasma membrane
- binds to side of F-actin filament so that both + (barbed) & - (pointed) ends are free
- binds with high affinity to vinculin & with low affinity to integrins
- interacts with PIP5K1C & NRAP
- interacts with LAYN
- interacts with SYNM
Structure:
- contains 1 FERM domain
- contains 1 I/LWEQ domain
Compartment:
- cell projection, ruffle membrane
- peripheral membrane protein; cytoplasmic side (putative)
- cytoplasm, cytoskeleton (putative
- colocalizes with LAYN at the membrane ruffles (putative)
- concentrated at regions of cell-substratum contact &, in lymphocytes, at cell-cell contacts
Interactions
molecular events
Related
talin-2 (TLN2, KIAA0320)
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 2541 aa
MW = 270 kD
COMPARTMENT: cytoplasm
MOTIF: Tyr phosphorylation site {Y26}
Tyr phosphorylation site {Y70}
FERM domain
NAME: FERM domain
SITE: 86-403
MOTIF: Thr phosphorylation site {T167}
LAYN interaction {280-435}
MOTIF: Ser phosphorylation site {S425}
Tyr phosphorylation site {Y436}
Tyr phosphorylation site {Y1116}
SYNM interaction {1327-1948}
MOTIF: Tyr phosphorylation site {Y1945}
Ser phosphorylation site {S2040}
Ser phosphorylation site {S2273}
I/LWEQ {2293-2533}
MOTIF: Ser phosphorylation site {S2338}
Database Correlations
OMIM 186745
UniProt Q9Y490
PFAM correlations
Entrez Gene 7094
Kegg hsa:7094
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 923
- Bishop JM.
Molecular themes in oncogenesis.
Cell. 1991 Jan 25;64(2):235-48. Review. No abstract available.
PMID: 1988146
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552
- Clark EA & Brugge JS
Integrins and signal transduction pathways: the road taken.
Science 268:233 1995
PMID: 7716514
- UniProt :accession Q9Y490
Component-of
molecular complex