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T-cell acute lymphocytic leukemia-2 protein (TAL2)
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
Pathology:
- chromosomal translocation t(7;9)(q34;q32) involving TAL2 with TCRB is associated with T-cell acute lymphoblastic leukemia (T-ALL)
Related
tal2 gene
General
basic helix loop helix (bHLH) family transcription factor
proto oncogene protein
transcription factor (TF)
Properties
SIZE: entity length = 108 aa
MW = 12 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 2-14
helix-loop-helix
NAME: helix-loop-helix
SITE: 15-55
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 186855
UniProt Q16559
Pfam PF00010
Kegg hsa:6887
References
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/TAL2ID28ch9q31.html
- UniProt :accession Q16559