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adenosylhomocysteinase 2; AdoHcyase 2; DC-expressed AHCY-like molecule; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1, DCAL, XPVKONA)
Function:
- amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1
- interacts with ITPR1
- competes with IP3 for interaction with ITPR1 & attenuates IP3-induced Ca+2 release through the ITPR1 from the endoplasmic reticulum
Cofactor: binds 1 NAD per subunit
Structure:
- the PEST region is essential for interaction with ITPR1
- the PDZ-binding region is required for maximal interaction with ITPR1 & is also responsible for the IP3-insensitive
- interaction with ITPR1 (putative)
- belongs to the adenosylhomocysteinase family
Compartment: endoplasmic reticulum (putative)
Alternative splicing: named isoforms=2
Expression:
- expressed in dendritic cells
- expression increases markedly during activation of blood & skin dendritic cells (Langerhans cells)
- expression is diminished in terminally differentiated tonsil dendritic cells
Related
inositol triphosphate [IP3] receptor P400 (ITPR, IP3-R)
inositol-1,4,5-triphosphate (IP3)
S-adenosyl homocysteine hydrolase (ADOHCYASE, adenosylhomocysteinase, AHCY, SAHH)
General
hydrolase
Properties
SIZE: entity length = 530 aa
MW = 59 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: Tyr phosphorylation site {Y28}
PEST {65-92}
MOTIF: Thr phosphorylation site {T82}
Ser phosphorylation site {S84}
Ser phosphorylation site {S85}
binding site
SITE: 155-155
FOR-BINDING-OF: Substrate
binding site
SITE: 229-229
FOR-BINDING-OF: Substrate
binding site
SITE: 254-254
FOR-BINDING-OF: Substrate
NAD binding {281-448}
MOTIF: binding site
SITE: 284-284
FOR-BINDING-OF: Substrate
binding site
SITE: 288-288
FOR-BINDING-OF: Substrate
cofactor-binding site [318-322]
COFACTOR-BOUND: NAD
cofactor-binding site [341-341]
COFACTOR-BOUND: NAD
cofactor-binding site [376-376]
COFACTOR-BOUND: NAD
Ser phosphorylation site {S391}
cofactor-binding site [397-399]
COFACTOR-BOUND: NAD
Ser phosphorylation site {S400}
Thr phosphorylation site {T402}
Thr phosphorylation site {T407}
binding site
SITE: 520-530
FOR-BINDING-OF: PDZ domain
Database Correlations
OMIM 607826
UniProt O43865
PFAM correlations
Entrez Gene 10768
Kegg hsa:10768
ENZYME 3.3.1.1
References
UniProt :accession O43865