dimethyladenosine transferase; DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1-like; probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; probable 18S rRNA dimethylase; probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase (DIMT1, DIMT1L, HUSSY-05)

Function: - specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S rRNA particle (putative) Structure: - belongs to the methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family Compartment: nucleus, nucleolus

General

demethylase nuclear protein N-methyltransferase

Properties

SIZE: entity length = 313 aa MW = 35 kD COMPARTMENT: cell nucleus MOTIF: binding site SITE: 37-37 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 39-39 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 64-64 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 85-85 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 113-113 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 128-128 FOR-BINDING-OF: S-adenosylmethionine

Database Correlations

OMIM 612499 UniProt Q9UNQ2 Pfam PF00398 Entrez Gene 27292 Kegg hsa:27292

References

UniProt :accession Q9UNQ2