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synembryn-B (brain synembrin, hSyn, protein Ric-8B)
Function:
- guanine nucleotide exchange factor (GEF)
- can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP
- able to potentiate Golf-alpha-dependent cAMP accumulation
- odorant signal transduction (putative)
- interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS & GNAQ
- does not interact with G-alpha proteins when they are in complex with subunits G-beta & G-gamma
Structure: belongs to the synembryn family
Compartment:
- cytoplasm, cell cortex
- localizes to cell cortex
Alternative splicing: named isoforms=4
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: MW = 61 kD
entity length = 536 aa
COMPARTMENT: cytoplasm
MOTIF: guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
Database Correlations
UniProt Q9NVN3
References
UniProt :accession Q9NVN3