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syncoilin-1; syncoilin intermediate filament 1 (SYNC1, SYNC)
interacts with DES & DTNA (putative)
Structure: belongs to the intermediate filament family
Compartment:
- cytoplasm, perinuclear region
- in skeletal muscle, colocalizes with DES & DTNA, & is localized at the myotendinous & neuromuscular junctions, sarcolemma & Z-lines
- in myotubes, detected in a punctate cytoplasmic pattern (putative)
Pathology:
- up-regulated at the sarcolemma in individuals with various forms of neuromuscular disease
General
intermediate filament protein
Properties
SIZE: entity length = 483 aa
MW = 56 kD
COMPARTMENT: cytoplasm
MOTIF: Head {1-161}
Rod {162-169}
Coil 1A {170-204}
Linker 1 {205-231}
Coil 1b {232-309}
Linker 2 {310-349}
Coil 2 {350-458}
Tail {459-483}
Database Correlations
UniProt Q9H7C4
References
UniProt :accession Q9H7C4