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synaptotagmin

Synaptotagmins 1-5. Possibly couples secretion to neuronal activity. A component of the neuronal secretory machinary without a yeast counterpart. Binds acidic phospholipids with a specificity that requires both an acidic headgroup & a diacyl backbone. Also facilitates actin-dependent filopodial extension of neurites [4]. Syntaxins associate with synaptotagmin.

Interactions

molecular events

Related

syntaxin

Specific

extended synaptotagmin-3 (E-Syt3, Chr3syt, protein FAM62C, FAM62C, ESYT3) Rab effector MyRIP; exophilin-8; myosin-VIIa- & Rab-interacting protein; synaptotagmin-like protein lacking C2 domains C; SlaC2-c; Slp homolog lacking C2 domains c (MYRIP, SLAC2C) synaptotagmin-10; synaptotagmin X; SytX (SYT10) synaptotagmin-11; synaptotagmin XI; SytXI (SYT11 KIAA0080) synaptotagmin-12; synaptotagmin XII; SytXII (SYT12) synaptotagmin-13; synaptotagmin XIII; SytXIII (SYT13, KIAA1427) synaptotagmin-14-like protein (synaptotagmin 14-like protein, synaptotagmin 14-derived protein, SYT14L, SYTDEP) synaptotagmin-14; synaptotagmin XIV; SytXIV (SYT14) synaptotagmin-15; synaptotagmin XV; SytXV; chr10Syt (SYT15) synaptotagmin-15B (SYT15B) synaptotagmin-16 (synaptotagmin 14-related protein, Chr14Syt, SYT16, STREP14, SYT14R) synaptotagmin-17 (synaptotagmin XVII, SytXVII, protein B/K, SYT17) synaptotagmin-1; synaptotagmin I; SytI; p65 (SYT1 SVP65 SYT) synaptotagmin-2; synaptotagmin II; SytII (SYT2) synaptotagmin-3; synaptotagmin III; SytIII (SYT3) synaptotagmin-4; synaptotagmin IV; SytIV (SYT4 KIAA1342) synaptotagmin-5; synaptotagmin V; SytV (SYT5) synaptotagmin-6; synaptotagmin VI; SytVI (SYT6) synaptotagmin-7; synaptotagmin VII; SytVII; prostate cancer-associated protein 7; IPCA-7 (SYT7, PCANAP7) synaptotagmin-8; synaptotagmin VIII; SytVIII (SYT8) synaptotagmin-9; synaptotagmin IX; SytIX (SYT9)

General

Ca+2 binding protein glycoprotein membrane protein oligomerizing protein

Properties

COMPARTMENT: cellular membrane MOTIF: glycosylation site membrane region Ca+2-binding site

References

  1. Perin MS, Brose N, Jahn R, Sudhof TC. Domain structure of synaptotagmin (p65) J Biol Chem. 1991 Jan 5;266(1):623-9. Erratum in: J Biol Chem 1991 May 25;266(15):10018. PMID: 1985919
  2. Allbritton NL, Meyer T, Stryer L. Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. Science. 1992 Dec 11;258(5089):1812-5. PMID: 1465619
  3. UniProt :accession P21579
  4. Feany MB, Buckley KM. The synaptic vesicle protein synaptotagmin promotes formation of filopodia in fibroblasts. Nature. 1993 Aug 5;364(6437):537-40. PMID: 8166886 - Kelly RB. Secretion. A question of endosomes. Nature. 1993 Aug 5;364(6437):487-8. PMID: 8336787
  5. Bennett MK, Miller KG, Scheller RH. Casein kinase II phosphorylates the synaptic vesicle protein p65. J Neurosci. 1993 Apr;13(4):1701-7. PMID: 8463845

Component-of

molecular complex