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synaptopodin-2 (myopodin, genethonin 2, SYNPO2)
Function:
- actin-binding & actin-bundling activity
- nuclear export is XPO1-dependent
Structure:
- belongs to the synaptopodin family
- contains 1 PDZ domain (DHR domain)
Compartment:
- nucleus, cytoplasm
- shuttles between nucleus & cytoplasm (differentiation- dependent, stress-induced)
- localizes to Z-disk in mature striated muscle
Related
synaptopodin (SYNPO, KIAA1029)
General
cytoskeletal protein
Properties
SIZE: MW = 118 kD
entity length = 1093 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PDZ domain
NAME: PDZ domain
SITE: 6-88
arginine-rich region {400-405}
MOTIF: arginine residue (SEVERAL)
glutamate-rich region {423-426}
MOTIF: glutamate residue (SEVERAL)
proline-rich region
SITE: 591-658
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 756-818
MOTIF: proline residue (SEVERAL)
serine-rich region {767-770}
MOTIF: serine residue (SEVERAL)
Database Correlations
UniProt Q9UMS6
Pfam PF00595
References
- UniProt :accession Q9UMS6
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/SYNPO2ID488.html