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synaptopodin (SYNPO, KIAA1029)
Function:
1) actin-associated protein
2) modulating actin-based shape & motility of
a) dendritic spines
b) renal podocyte foot processes
3) formation of spine apparatuses in spines of neurons
4) synaptic plasticity
5) isoform 2 is phosphorylated on Ser-826, Thr-836, Ser-840 & Ser-871
6) interacts with BAIAP1, actin
7) interacts (via PPxY motifs) with WWC1 (via WW domains)
Structure:
- O-glycosylated (putative)
- belongs to the synaptopodin family
Compartment:
- cytoplasm
- localized to tight junctions
- in brain, localized to postsynaptic densities & perikarya
- associated with dendritic spines of a subset of synapses
Alternative splicing: named isoforms=3
Expression: expressed in cerebral cortex
Related
synaptopodin-2 (myopodin, genethonin 2, SYNPO2)
General
cytoskeletal protein
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 929 aa
MW = 99 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S263}
N-glycosylation site {N330}
Tyr phosphorylation site {Y466}
Ser phosphorylation site {S501}
Ser phosphorylation site {S525}
Ser phosphorylation site {S548}
PPxY {562-565}
Ser phosphorylation site {S580}
PPxY {581-584}
Ser phosphorylation site {S685}
Ser phosphorylation site {S702}
Thr phosphorylation site {T746}
proline-rich region
SITE: 753-908
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S754}
Ser phosphorylation site {S758}
Ser phosphorylation site {S833}
Ser phosphorylation site {S882}
Database Correlations
OMIM 608155
UniProt Q8N3V7
Entrez Gene 11346
Kegg hsa:11346
References
UniProt :accession Q8N3V7