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synaptophysin; major synaptic vesicle protein p38 (SYP)
Function:
- possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane
- ubiquitinated; mediated by SIAH1 or SIAH2 & leading to its subsequent proteasomal degradation (putative)
Structure:
- homohexamer or homotetramer
- the Ca+2-binding activity is thought to be localized in the cytoplasmic tail of the protein
- belongs to the synaptophysin/synaptobrevin family
- contains 1 MARVEL domain
Compartment:
- cytoplasmic vesicle, secretory vesicle
- synaptic vesicle membrane
- cell junction, synapse, synaptosome
- may colocalize with the amyloid precursor protein (APP)
Expression:
- characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal & epithelial phenotype
Related
synaptophysin Ag in tissue
General
glycoprotein
ion channel
oligomerizing protein
transmembrane 4 protein
Properties
SIZE: entity length = 313 aa
MW = 34 kD
COMPARTMENT: cytoplasm
synaptic vesicle
CELL-REGION: axon terminal
CELL: neuron
WITHIN: brain
MOTIF: cytoplasmic domain {1-25}
transmembrane domain {26-49}
exoplasmic loop {50-106}
MOTIF: N-glycosylation site {N59}
Tyr phosphorylation site {Y81}
transmembrane domain {107-130}
cytoplasmic loop {131-137}
transmembrane domain {138-161}
exoplasmic loop {162-199}
transmembrane domain {200-223}
cytoplasmic domain {224-313}
Database Correlations
OMIM 313475
UniProt P08247
Entrez Gene 6855
Kegg hsa:6855
References
- Mandell JW et al
Synapsins in the vertebrate retina: absence from ribbon
synapses and heterogeneous distribution among conventional
synapses.
Neuron 1990 Jul;5(1):19-33
PMID: 2114884
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 791
- Entrez Gene :accession 6855
- UniProt :accession P08247
- Wikipedia; Note: synaptophysin entry
http://en.wikipedia.org/wiki/synaptophysin