synaptonemal complex protein 3 (SCP-3, SYCP3, SCP3)

Function: 1) component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase 2) meiotic function in spermatogenesis 3) testis development 4) interacts with SYCP2 Compartment: - nucleus - in tripartite segments of synaptonemal complexes Expression: testis-specific Pathology: - defects in SYCP3 are associated with azoospermia due to perturbations of meiosis

General

nuclear protein testis-specific protein

Properties

SIZE: MW = 28 kD entity length = 236 aa COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {88-91} glutamine-rich region {105-232} MOTIF: glutamine residue (SEVERAL) coiled coil {139-223}

Database Correlations

OMIM correlations UniProt Q8IZU3 Pfam PF04803

References

UniProt :accession xxx