synaptonemal complex protein 1; SCP-1; cancer/testis antigen 8; CT8 (SYCP1, SCP1)

Function: - major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase - found in a complex with SYCE1 & SYCE2 - interacts with SYCE1 & SYCE2 (putative) Structure: - consists of an alpha-helical stretch of 700 AA residues, flanked by N- & C-terminal globular domains - the C-terminal domain has DNA-binding capacity (putative) Compartment: - nucleus (putative) - in tripartite segments of synaptonemal complexes, between lateral elements in the nucleus - found only where the chromosome cores are synapsed - its N-terminus is found towards the center of the synaptonemal complex; the C-terminus extends well into the lateral domain of the synaptonemal complex (putative) Expression: testis

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 976 aa MW = 114 kD COMPARTMENT: cell nucleus MOTIF: acidic region {12-100} MOTIF: acidic residue (SEVERAL) coiled coil {107-798} MOTIF: nuclear translocation signal {117-120} Tyr phosphorylation site {Y257} nuclear translocation signal {679-682} nuclear translocation signal {880-883} lysine-rich region {961-969} MOTIF: lysine residue (SEVERAL)

Database Correlations

OMIM 602162 UniProt Q15431 Pfam PF05483 Entrez Gene 6847 Kegg hsa:6847

References

UniProt :accession Q15431