synaptobrevin homolog YKT6

Function: 1) vesicular soluble NSF attachment protein receptor (v-SNARE) 2) mediates vesicle docking & fusion to a specific acceptor cellular compartment 3) functions in endoplasmic reticulum to Golgi transport 4) component of a SNARE complex containing GOSR1, GOSR2 & STX 5) functions in early/recycling endosome to TGN transport, as part of a SNARE complex containing of BET1L, GOSR1 & STX5 6) S-palmitoyl transferase 7) component of 2 different SNARE complexes Structure: - longin domain regulates palmitoylation & membrane targeting - palmitoylated - catalyzes its own palmitoylation - palmitoylation is required for Golgi targeting - farnesylation is required for Golgi targeting - belongs to the synaptobrevin family - contains 1 longin domain - contains 1 v-SNARE coiled-coil homology domain Compartment: - cytoplasm - vesicle & Golgi membrane, lipid-anchor, cytoplasmic side - probably cycles through vesicles between Golgi & endosomes

Properties

SIZE: MW = 22 kD entity length = 198 aa COMPARTMENT: cytoplasm golgi MOTIF: Longin {8-126} SNARE motif {138-198} MOTIF: cysteine residue {C194} MODIFICATION: palmitate COMPARTMENT: membrane CaaX motif SITE: C-TERMINUS EFFECTOR-BOUND: farnesyl

Database Correlations

OMIM 606209 UniProt O15498 Pfam PF00957

References

UniProt :accession O15498