synaptic vesicle glycoprotein 2C (SV2C, KIAA1054)

Function: 1) control of regulated secretion in neural & endocrine cells 2) selectively lenhances low-frequency neurotransmission 3) positively regulates vesicle fusion by maintaining readily releasable pool of secretory vesicles (putative) 4) interacts with SYT1 (Ca+-dependent) 5) N-glycosylated Compartment: - cytoplasmic vesicle, secretory vesicle, synaptic vesicle, - synaptic vesicle membrane - enriched in small synaptic vesicles & adrenal microsomes - not present in chromaffin granules - associated with both insulin granules & synaptic-like microvesicles in insulin-secreting cells of the pancreas

General

glycoprotein transmembrane 12 protein

Properties

SIZE: MW = 82 kD entity length = 727 aa COMPARTMENT: cytoplasm MOTIF: cytoplasmic domain {1-154} MOTIF: binding site SITE: 1-57 FOR-BINDING-OF: synaptotagmin-1 transmembrane domain {155-175} exoplasmic loop {176-191} transmembrane domain {192-212} cytoplasmic loop {213-226} transmembrane domain {227-247} exoplasmic loop {248-248} transmembrane domain {249-269} cytoplasmic loop {270-280} transmembrane domain {281-301} exoplasmic loop {302-320} transmembrane domain {321-341} cytoplasmic loop {342-437} transmembrane domain {438-458} exoplasmic loop {459-578} MOTIF: N-glycosylation site {N480} N-glycosylation site {N484} N-glycosylation site {N534} N-glycosylation site {N559} N-glycosylation site {N565} transmembrane domain {579-599} cytoplasmic loop {600-609} transmembrane domain {610-630} exoplasmic loop {631-636} transmembrane domain {637-657} cytoplasmic loop {658-669} transmembrane domain {670-690} exoplasmic loop {691-698} transmembrane domain {699-719} cytoplasmic domain {720-727}

Database Correlations

UniProt Q496J9 Pfam PF07690

References

UniProt :accession Q496J9