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synaptic vesicle glycoprotein 2B (SV2B, KIAA0735)
Function:
1) control of regulated secretion in neural & endocrine cells
2) interacts with SYT1 (Ca+2-dependent)
3) forms a complex with SYT1, syntaxin-1 & SNAP25
4) N-glycosylated
Compartment:
- cytoplasmic vesicle, secretory vesicle, synaptic vesicle, synaptic vesicle membrane, acrosome
- associated with synaptic-like microvesicles but NOT with insulin-containing vesicles in insulin-secreting cells of the pancreas
- localizes to microvesicles in the pinealocytes
- localizes to the acrosome in spermatids
General
glycoprotein
transmembrane 12 protein
Properties
SIZE: MW = 77 kD
entity length = 683 aa
COMPARTMENT: cytoplasm
MOTIF: cytoplasmic domain {1-108}
transmembrane domain {109-129}
exoplasmic loop {130-148}
transmembrane domain {149-169}
cytoplasmic loop {170-182}
transmembrane domain {183-203}
exoplasmic loop {204-205}
transmembrane domain {206-226}
cytoplasmic loop {227-237}
transmembrane domain {238-258}
exoplasmic loop {259-277}
transmembrane domain {278-298}
cytoplasmic loop {299-390}
transmembrane domain {391-411}
exoplasmic loop {412-535}
MOTIF: N-glycosylation site {N441}
N-glycosylation site {N491}
N-glycosylation site {N516}
transmembrane domain {536-556}
cytoplasmic loop {557-565}
transmembrane domain {566-586}
exoplasmic loop {587-592}
transmembrane domain {593-613}
cytoplasmic loop {614-626}
transmembrane domain {627-649}
exoplasmic loop {650-653}
transmembrane domain {654-672}
cytoplasmic domain {673-683}
Database Correlations
OMIM 185861
UniProt Q7L1I2
Pfam PF07690
References
UniProt :accession Q7L1I2