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synapsin-3; synapsin III (SYN3)
Function:
- may be involved in regulation of neurotransmitter release & synaptogenesis
- interacts with CAPON (putative)
- regulated by Ca+2
- Ca+2 inhibits ATP binding to the C-domain
Structure: belongs to the synapsin family
Compartment:
- cytoplasmic vesicle
- secretory vesicle
- synaptic vesicle membrane
- peripheral membrane protein cytoplasmic side
- peripheral membrane protein localized to cytoplasmic surface of synaptic vesicles
Expression:
- neuron specific
- detected predominantly in brain
General
synapsin
Properties
SIZE: entity length = 580 aa
MW = 63 kD
COMPARTMENT: cytoplasm
MOTIF: A {1-28}
B; linker {28-90}
binding site
SITE: 91-399
FOR-BINDING-OF: actin
J; Pro-rich linker {400-531}
MOTIF: Ser phosphorylation site {S462}
Ser phosphorylation site {S470}
Ser phosphorylation site {S484}
E {532-580}
Database Correlations
OMIM 602705
UniProt O14994
PFAM correlations
Entrez Gene 8224
Kegg hsa:8224
References
UniProt :accession O14994