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synapsin-2; synapsin II (SYN2)
Function:
- neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, & is believed to function in regulation of neurotransmitter release (putative)
- interacts with CAPON (putative)
Structure: belongs to the synapsin family
Compartment: cell junction, synapse
Alternative splicing: named isoforms=2; IIa; Ib
Expression:
- expressed in central nervous system & peripheral nervous system (probable)
General
synapsin
Properties
SIZE: entity length = 582 aa
MW = 63 kD
COMPARTMENT: cytoplasm
MOTIF: A {1-29}
B; linker {33-112}
MOTIF: proline-rich region
SITE: 34-42
MOTIF: proline residue (SEVERAL)
binding site
SITE: 113-420
FOR-BINDING-OF: actin
G; Pro-rich linker {421-457}
MOTIF: Thr phosphorylation site {T421}
Ser phosphorylation site {S425}
H; Pro/Ser-rich linker {458-533}
MOTIF: serine-rich region {486-496}
MOTIF: serine residue (SEVERAL)
serine-rich region {512-516}
MOTIF: serine residue (SEVERAL)
E {534-582}
Database Correlations
OMIM 600755
UniProt Q92777
PFAM correlations
References
- UniProt :accession Q92777
- Mandell JW et al
Synapsins in the vertebrate retina: absence from ribbon
synapses and heterogeneous distribution among conventional
synapses.
Neuron 1990 Jul;5(1):19-33
PMID: 2114884