AT-rich interactive domain-containing protein 1A; ARID domain-containing protein 1A; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SWI/SNF complex protein p270; B120; SWI-like protein; Osa homolog 1; hOSA1; hELD; BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A (ARID1A, BAF250, BAF250A, C1orf4, OSA1, SMARCF1)

Function: - role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) - binds DNA non-specifically - associatEd with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor - component of the BAF complex(SWI/SNF-A complex) - component of npBAF complex) & nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons - component of SWI/SNF chromatin remodeling complexes - phosphorylated upon DNA damage, probably by ATM or ATR - component of the SWI/SNF-B complex (PBAF complex) - component of the SWI/SNF Brm complex - component of the SWI/SNF complex Brg1(I) - component of the SWI/SNF complex Brg1(II) - component of a SWI/SNF-like EPAFa complex - component of a SWI/SNF-like complex containing ARID1A/BAF250A & ARID1B/BAF250B - interacts through its C- terminus with SMARCA2/BRM/BAF190B & SMARCA4/BRG1/BAF190A - interacts with SMARCC1/BAF155 Structure: contains 1 ARID domain Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - highly expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, & peripheral blood leukocytes - expressed at a much lower level in heart, brain, placenta, lung, liver, skeletal muscle, kidney, & pancreas

General

DNA-binding protein nuclear protein phosphoprotein SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily F

Properties

SIZE: entity length = 2285 aa MW = 242 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S79} Ser phosphorylation site {S233} Thr phosphorylation site {T286} LXXLL {295-299} Ser phosphorylation site {S363} Ser phosphorylation site {S382} glutamine-rich region {479-482} MOTIF: glutamine residue (SEVERAL) glutamine-rich region {561-567} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S604} Ser phosphorylation site {S696} Ser phosphorylation site {S698} Ser phosphorylation site {S702} Ser phosphorylation site {S764} Ser phosphorylation site {S772} serine-rich region {998-1001} MOTIF: serine residue (SEVERAL) ARID {1017-1108} Ser phosphorylation site {S1184} glutamine-rich region {1327-1404} MOTIF: glutamine residue (SEVERAL) LXXLL {1709-1713} Ser phosphorylation site {S1755} Ser phosphorylation site {S1944} LXXLL {1967-1971} LXXLL {2085-2089}

Database Correlations

OMIM 603024 UniProt O14497 PFAM correlations Entrez Gene 8289 Kegg hsa:8289

References

UniProt :accession O14497