SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related; SMARCE1-related protein; HMG box-containing protein 20B; HMG domain-containing protein HMGX2; HMG domain-containing protein 2; structural DNA-binding protein BRAF35; BRCA2-associated factor 35; Sox-like transcriptional factor (HMG20B, BRAF35, HMGX2, HMGXB2, SMARCE1R)

Function: - required for correct progression through G2 phase of the cell cycle & entry into mitosis - required for RCOR1/CoREST mediated repression of neuronal specific gene promoters - component of a BHC histone deacetylase complex - interacts with the BRCA2 tumor suppressor protein Structure: - contains 1 HMG box DNA-binding domain Compartment: - nucleus - localized to condensed chromosomes in mitosis in conjunction with BRCA2 Alternative splicing: named isoforms=3 Expression: ubiquitously expressed in adult tissues

General

nuclear protein SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily E

Properties

SIZE: entity length = 317 aa MW = 36 kD COMPARTMENT: cell nucleus MOTIF: HMG box SITE: 70-138 coiled coil {190-257}

Database Correlations

OMIM 605535 UniProt Q9P0W2 Pfam PF00505 Entrez Gene 10362 Kegg hsa:10362

References

UniProt :accession Q9P0W2