SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BRG1-associated factor 57; BAF57 (SMARCE1, BAF57)

Function: - role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) - component of the BAF complex - component of npBAF complex & nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons - association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor - required for coactivation of estrogen responsive promoters by Swi/Snf complexes & the SRC/p160 family of histone acetyltransferases (HATs) - specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells - component of multiprotein chromatin-remodeling complexes: a) Swi/Snf-A complex (BAF complex) b) Swi/Snf-B complex (PBAF complex) c) Brm complex d) Brg1(I) complex e) WINAC complex f) Brg1(II) complex - binds to the SRC/p160 family of histone acetyltransferases composed of NCOA1, NCOA2, & NCOA3 Structure: - HMG domain is essential for CD4 silencing & CD8 activation; mutation of this domain blocks thymus development - contains 1 HMG box DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=2

General

nuclear protein phosphoprotein SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily E

Properties

SIZE: entity length = 411 aa MW = 47 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 5-65 MOTIF: proline residue (SEVERAL) HMG box SITE: 66-134 coiled coil {220-319} MOTIF: Ser phosphorylation site {S265} glutamate-rich region {320-411} MOTIF: glutamate residue (SEVERAL)

Database Correlations

OMIM 603111 UniProt Q969G3 Pfam PF00505 Entrez Gene 6605 Kegg hsa:6605

References

UniProt :accession Q969G3