SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; 60 kD BRG-1/Brm-associated factor subunit C; BRG1-associated factor 60C; BAF60C (SMARCD3, BAF60C)

Function: - role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes - stimulates nuclear receptor mediated transcription - component of the BAF complex - component of npBAF complex & nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons - interacts with SMARCA4/BRG1/BAF190A, the catalytic subunit of the SWI/SNF related nucleosome-remodeling complexes BRG1(I) & BRG1(II) - also interacts with several nuclear receptors including PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1/SF1, NR5A2/LRH1 & other transcriptional activators including the HLH protein SREBF1/SREBP1 & the homeobox protein PBX1 - may allow recruitment of Swi/SNF containing complexes specifically to promoters where these factors are located Structure: - belongs to the SMARCD family - contains 1 SWIB domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - isoform 2 & isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea & uterus - isoform 1 is also expressed in skeletal muscle & adipose tissue

General

BRG1 associated factor nuclear protein phosphoprotein SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily D

Properties

SIZE: entity length = 483 aa MW = 55 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S178} SWIB {259-334}

Database Correlations

OMIM 601737 UniProt Q6STE5 Pfam PF02201 Entrez Gene 6604 Kegg hsa:6604