SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; SWI/SNF complex 60 kD subunit; 60 kD BRG-1/Brm-associated factor subunit A; BRG1-associated factor 60A; BAF60A (SMARCD1, BAF60A)

Function: - role in chromatin remodeling - component of the BAF complex - component of npBAF complex & nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons - component of the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor - strong influence on the vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE) - may be a link between mammalian SWI-SNF-like chromatin remodeling complexes & the vitamin D receptor heterodimer - mediates interactions between nuclear receptors & the BRG1/SMARCA4 chromatin-remodeling complex for transactivation Structure: - belongs to the SMARCD family - contains 1 SWIB domain Compartment: nucleus (probable) Alternative splicing: named isoforms=2 Expression: - expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas & placenta

General

BRG1 associated factor nuclear protein SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily D

Properties

SIZE: entity length = 515 aa MW = 58 kD COMPARTMENT: cell nucleus MOTIF: multiple interactions {43-167} MOTIF: lysine-rich region {124-127} MOTIF: lysine residue (SEVERAL) SMARCC1/SMARCC2 interaction {168-474} domain {180-515} MOTIF: SWIB {291-390} coiled coil {412-440}

Database Correlations

OMIM 601735 UniProt Q96GM5 Pfam PF02201 Entrez Gene 6602 Kegg hsa:6602

References

UniProt :accession Q96GM5