SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI/SNF complex subunit SMARCC2; SWI/SNF complex 170 kD subunit; BRG1-associated factor 170; BAF170 (SMARCC2, BAF170)

Function: - role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) - can stimulate the ATPase activity of the catalytic subunit of these complexes - may be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells - associated with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor - component of the npBAF complex & the nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons - component of multiprotein chromatin-remodeling complexes: a) Swi/Snf-A complex (BAF complex) b) Swi/Snf-B complex (PBAF complex) c) Brm complex d) Brg1(I) complex e) WINAC complex f) Brg1(II) complex - may also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 & SMARCA4 Structure: - belongs to the SMARCC family - contains 1 SANT domain - contains 1 SWIRM domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: ubiquitously expressed

General

BRG1 associated factor nuclear protein phosphoprotein SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily C

Properties

SIZE: entity length = 1214 aa MW = 133 kD COMPARTMENT: cell nucleus MOTIF: glutamate-rich region {186-189} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S283} Ser phosphorylation site {S286} Tyr phosphorylation site {Y296} Ser phosphorylation site {S302} Ser phosphorylation site {S304} Ser phosphorylation site {S306} Thr phosphorylation site {T322} Ser phosphorylation site {S347} SWIRM {424-521} SANT {596-647} glutamate-rich region {747-855} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S806} Ser phosphorylation site {S810} alanine-rich region {861-870} MOTIF: alanine residue (SEVERAL) coiled coil {907-934} glutamine-rich region {956-960} MOTIF: glutamine residue (SEVERAL) proline-rich region SITE: 961-1213 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 601734 UniProt Q8TAQ2 PFAM correlations Entrez Gene 6601