SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI/SNF complex subunit SMARCC1; SWI/SNF complex 155 kD subunit; BRG1-associated factor 155; BAF155 (SMARCC1, BAF155)

Function: - role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) - associated with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor - component of the npBAF complex & the nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic - phosphorylated on undefined residues at the G2/M transition by ERK1 & other kinases; this may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein - component of multiprotein chromatin-remodeling complexes: a) Swi/Snf-A complex (BAF complex) b) Swi/Snf-B complex (PBAF complex) c) Brm complex d) Brg1(I) complex e) WINAC complex f) Brg1(II) complex - may stimulate the ATPase activity of the catalytic subunit of the complex (either SMARCA4 or SMARCA2) - may also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 & SMARCA4 - the minimal complex composed of SMARCC1 & SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1 - interacts with NR3C1 & SMARD1 Structure: - belongs to the SMARCC family - contains 1 SANT domain - contains 1 SWIRM domain Compartment: nucleus Expression: - expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney & pancreas

General

BRG1 associated factor nuclear protein phosphoprotein SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily C

Properties

SIZE: entity length = 1105 aa MW = 123 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S301} Ser phosphorylation site {S310} Ser phosphorylation site {S319} Ser phosphorylation site {S328} proline-rich region SITE: 329-336 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S330} Thr phosphorylation site {T335} Thr phosphorylation site {T337} Ser phosphorylation site {S339} Ser phosphorylation site {S357} SWIRM {449-546} Ser phosphorylation site {S573} SANT {618-669} glutamate-rich region {769-863} MOTIF: glutamate residue (SEVERAL) alanine-rich region {867-878} MOTIF: alanine residue (SEVERAL) coiled coil {914-946} proline-rich region SITE: 977-1105 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 601732 UniProt Q92922 PFAM correlations Entrez Gene 6599 Kegg hsa:6599

References

UniProt :accession Q92922