SWI/SNF-like EPAFb chromatin remodeling complex

Function: - chromatin remodeling Structure: - consists of: - SMARCA4/BRG1 - SMARCB1/BAF47 - ACTL6A/BAF53A - SMARCE1/BAF57 - SMARCD1/BAF60A - SMARCD2/BAF60B - SMARCC1/BAF155 - SMARCC2/BAF170, - ARID1B/BAF250B - MLLT1/ENL - actin

Properties

COMPARTMENT: cell nucleus SUBUNITS: transcription activator BRG1 COMPARTMENT: cell nucleus MOTIF: SS18L1/CREST interaction {1-282} MOTIF: Thr phosphorylation site {T11} HSA {460-532} lysine-rich region {578-588} MOTIF: lysine residue (SEVERAL) Thr phosphorylation site {T609} Ser phosphorylation site {S610} Ser phosphorylation site {S613} Ser phosphorylation site {S655} Ser phosphorylation site {S657} Ser phosphorylation site {S660} Ser phosphorylation site {S662} glutamate-rich region {663-672} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S695} Ser phosphorylation site {S699} Ser phosphorylation site {S721} helicase NAME: helicase SITE: 766-931 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 779-786 DEAD/H box NAME: DEAD/H box SITE: 881-884 Helicase C-terminal {1084-1246} glutamate-rich region {1360-1364} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S1382} Ser phosphorylation site {S1452} bromodomain {1477-1547} MOTIF: peptide motif {1539-1540} Ser phosphorylation site {S1570} glutamate-rich region {1571-1584} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S1575} Ser phosphorylation site {S1586} Ser phosphorylation site {S1627} Ser phosphorylation site {S1631} Ser phosphorylation site {S1640} Ser phosphorylation site {S1642} Ser phosphorylation site {S1644} SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 COMPARTMENT: cell nucleus MOTIF: binding site SITE: 106-183 FOR-BINDING-OF: deoxyribonucleic acid (DNA) MOTIF: Ser phosphorylation site {S129} binding site SITE: 183-243 FOR-BINDING-OF: HIV-1 INTEGRASE tandem repeats {186-319} MOTIF: consensus repeat {186-245} binding site SITE: 186-245 FOR-BINDING-OF: myc protein family consensus repeat {259-319} PPP1R15A interaction {304-318} actin-like protein 6A COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S233} SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 5-65 MOTIF: proline residue (SEVERAL) HMG box SITE: 66-134 coiled coil {220-319} MOTIF: Ser phosphorylation site {S265} glutamate-rich region {320-411} MOTIF: glutamate residue (SEVERAL) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 COMPARTMENT: cell nucleus MOTIF: multiple interactions {43-167} MOTIF: lysine-rich region {124-127} MOTIF: lysine residue (SEVERAL) SMARCC1/SMARCC2 interaction {168-474} domain {180-515} MOTIF: SWIB {291-390} coiled coil {412-440} SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 COMPARTMENT: cell nucleus MOTIF: Thr phosphorylation site {T142} SWIB {232-307} Thr phosphorylation site {T408} SWI/SNF complex subunit SMARCC1 COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S301} Ser phosphorylation site {S310} Ser phosphorylation site {S319} Ser phosphorylation site {S328} proline-rich region SITE: 329-336 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S330} Thr phosphorylation site {T335} Thr phosphorylation site {T337} Ser phosphorylation site {S339} Ser phosphorylation site {S357} SWIRM {449-546} Ser phosphorylation site {S573} SANT {618-669} glutamate-rich region {769-863} MOTIF: glutamate residue (SEVERAL) alanine-rich region {867-878} MOTIF: alanine residue (SEVERAL) coiled coil {914-946} proline-rich region SITE: 977-1105 MOTIF: proline residue (SEVERAL) SWI/SNF complex subunit SMARCC2 COMPARTMENT: cell nucleus MOTIF: glutamate-rich region {186-189} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S283} Ser phosphorylation site {S286} Tyr phosphorylation site {Y296} Ser phosphorylation site {S302} Ser phosphorylation site {S304} Ser phosphorylation site {S306} Thr phosphorylation site {T322} Ser phosphorylation site {S347} SWIRM {424-521} SANT {596-647} glutamate-rich region {747-855} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S806} Ser phosphorylation site {S810} alanine-rich region {861-870} MOTIF: alanine residue (SEVERAL) coiled coil {907-934} glutamine-rich region {956-960} MOTIF: glutamine residue (SEVERAL) proline-rich region SITE: 961-1213 MOTIF: proline residue (SEVERAL) AT-rich interactive domain-containing protein 1B COMPARTMENT: NUCL :NAME ARID MOTIF: DNA-binding motif protein ENL COMPARTMENT: cell nucleus MOTIF: YEATS {8-112} Ser phosphorylation site {S155} Ser phosphorylation site {S209} proline-rich region SITE: 272-280 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S292} Ser phosphorylation site {S296} Ser phosphorylation site {S315} serine-rich region {319-325} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S359} Ser phosphorylation site {S361} Ser phosphorylation site {S366} serine-rich region {374-389} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 457-460 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 463-466 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S475} actin MOTIF: coiled coil

References

UniProt :accession Q15813

Components

actin actin-like protein 6A; 53 kD BRG1-associated factor A; actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K (ACTL6A, BAF53, BAF53A, INO80K) AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B, Osa homolog 2, hOsa2, p250R, BRG1-binding protein hELD/OSA1, BRG1-associated factor 250b, BAF250B, ARID1B, DAN15, KIAA1235, OSA2) ENL (eleven-nineteen leukemia) proto oncogene protein; protein ENL; YEATS domain-containing protein 1 (MLLT1 ENL LTG19 YEATS1) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; transcription activator BRG1; ATP-dependent helicase SMARCA4; SNF2-beta; protein BRG-1; mitotic growth & transcription activator; protein brahma homolog 1; BRG1-associated factor 190A; BAF190A (SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; integrase interactor 1 protein; SNF5 homolog; hSNF5; BRG1-associated factor 47; BAF47 (SMARCB1, BAF47, INI1, SNF5L1) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI/SNF complex subunit SMARCC1; SWI/SNF complex 155 kD subunit; BRG1-associated factor 155; BAF155 (SMARCC1, BAF155) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI/SNF complex subunit SMARCC2; SWI/SNF complex 170 kD subunit; BRG1-associated factor 170; BAF170 (SMARCC2, BAF170) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; SWI/SNF complex 60 kD subunit; 60 kD BRG-1/Brm-associated factor subunit A; BRG1-associated factor 60A; BAF60A (SMARCD1, BAF60A) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; 60 kD BRG-1/Brm-associated factor subunit B; BRG1-associated factor 60B; BAF60B (SMARCD2, BAF60B, PRO2451) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BRG1-associated factor 57; BAF57 (SMARCE1, BAF57)