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chloride (Cl-) in sweat

Indications: - sweat chloride using pilocarpine iontophoresis is the gold standard for diagnosis of cystic fibrosis (CF) * measured along with sodium in sweat Clinical significance: 1) normal is < 30 meq/L [2] 2) > 80 meq/L is abnormal in adults 3) > 60 meq/L is abnormal in children 4) abnormal results on at least 2 tests is necessary for diagnosis of cystic fibrosis; (2 weeks & 4 months) [2] 5) other conditions associated with high sweat [Na+] & [Cl-] a) smoking b) chronic bronchitis c) malnutrition d) hereditary nephrogenic diabetes insipidus e) adrenal insufficiency 6) ectodermal dysplasia Increases: - cystic fibrosis Notes: - sweat sodium is generally measured along with chloride as confirmation of the measured chloride value.

Related

cystic fibrosis (CF, mucoviscidosis) pilocarpine iontophoresis

General

chloride (Cl-) in body fluid

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 745
  2. McCarthy C, Clancy JP, Brewington J. Sweat Chloride Testing JAMA. Published online January 30, 2019 PMID: 30698611 https://jamanetwork.com/journals/jama/fullarticle/2723632