SWAP complex

Structure: - consists of: NPM1, NCL, PARP1 & SWAP70

Properties

SUBUNITS: NPM1 nucleolin COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S28} Ser phosphorylation site {S34} Ser phosphorylation site {S41} Ser phosphorylation site {S42} 8 X 8 AA tandem repeats of X-T-P-X-K-K-X- X {58-135} MOTIF: consensus repeat {58-65} Ser phosphorylation site {S67} Thr phosphorylation site {T69} consensus repeat {75-82} Thr phosphorylation site {T76} consensus repeat {83-90} consensus repeat {91-98} consensus repeat {99-104} Thr phosphorylation site {T99} consensus repeat {105-112} Thr phosphorylation site {T105} consensus repeat {120-127} Thr phosphorylation site {T121} consensus repeat {128-135} acidic region {143-171} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S145} Ser phosphorylation site {S153} Ser phosphorylation site {S184} acidic region {185-209} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S206} Thr phosphorylation site {T214} acidic region {234-271} MOTIF: acidic residue (SEVERAL) RNP motif NAME: RNP motif SITE: 307-383 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Thr phosphorylation site {T367} RNP motif NAME: RNP motif SITE: 393-466 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 486-560 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S563} RNP motif NAME: RNP motif SITE: 572-647 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S580} Ser phosphorylation site {S619} poly [ADP-ribose] polymerase 1 COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 2-372 acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Zn finger PARP-type NAME: Zn finger PARP-type SITE: 9-93 EFFECTOR-BOUND: Zn+2 MOTIF: Ser phosphorylation site {S41} Zn finger PARP-type NAME: Zn finger PARP-type SITE: 113-203 EFFECTOR-BOUND: Zn+2 MOTIF: Ser phosphorylation site {S179} nuclear translocation signal {207-209} nuclear translocation signal {221-226} Thr phosphorylation site {T368} Automodification {373-524} MOTIF: BRCA1 C-terminal (BRCT) motif SITE: 385-476 PARP alpha-helical {662-779} Ser phosphorylation site {S782} catalytic domain SITE: 788-1014 switch-associated protein 70 COMPARTMENT: cytoplasm cell nucleus MOTIF: PH domain {210-306} MOTIF: lysine-rich region {291-294} MOTIF: lysine residue (SEVERAL) coiled coil {316-539}

References

UniProt :accession Q9UGP8

Components

nucleolin; protein C23 (NCL) poly [ADP-ribose] polymerase 1; PARP-1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; poly[ADP-ribose] synthase 1 (PARP1, ADPRT, PPOL) switch-associated protein 70 (SWAP-70, SWAP70, KIAA0640, HSPC321)