Search
Sushi, von Willebrand factor type A, EGF & pentraxin domain-containing protein 1 (polydom, selectin-like osteoblast-derived protein, SEL-OB, CCP module-containing protein 22, serologically defined breast cancer antigen NY-BR-38, SVEP1, C9orf13, CCP22, SELOB)
Function:
- may play a role in the cell attachment process
Structure:
- contains 9 EGF-like domains
- contains 2 HYR domains
- contains 1 pentraxin domain
- contains 34 Sushi domains (CCP/SCR) domains
- contains 1 VWFA domain
Compartment: secreted, cytoplasm; peripheral membrane
Alternative splicing: named isoforms=4
Expression:
- present in mesenchymal primary cultured cell lysates (at protein level)
- highly expressed in placenta
- also expressed in marrow stromal cell
- weakly or not expressed in other tissues
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 3574 aa
MW = 391 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-17}
VWFA domain {83-264}
MOTIF: N-glycosylation site {N186}
Sushi domain {376-3473} (34)
MOTIF: cysteine residue {C378}
MODIFICATION: cysteine residue {C420}
cysteine residue {C406}
MODIFICATION: cysteine residue {C433}
cysteine residue {C420}
MODIFICATION: cysteine residue {C378}
cysteine residue {C433}
MODIFICATION: cysteine residue {C406}
HYR 1 {560-642}
HYR 2 {643-724}
N-glycosylation site {N847}
N-glycosylation site {N1102}
EGF domain {1193-3567} (9)
MOTIF: cysteine residue {C1197}
MODIFICATION: cysteine residue {C1208}
cysteine residue {C1202}
MODIFICATION: cysteine residue {C1217}
cysteine residue {C1208}
MODIFICATION: cysteine residue {C1197}
cysteine residue {C1217}
MODIFICATION: cysteine residue {C1202}
cysteine residue {C1219}
MODIFICATION: cysteine residue {C1228}
cysteine residue {C1228}
MODIFICATION: cysteine residue {C1219}
Pentraxin {1430-1626}
Database Correlations
UniProt Q4LDE5
PFAM correlations
Kegg hsa:7998
References
UniProt :accession Q4LDE5