survival of motor neuron protein-interacting protein 1; SMN-interacting protein 1; component of gems 2; Gemin-2 (SIP1, GEMIN2)

Function: - forms complex with survival motor neuron protein-1 - component of the core SMN complex - interacts directly with GEMIN5 Structure: belongs to the gemin-2 family Compartment: - nucleus, gem, cytoplasm - localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs - also found in the cytoplasm Alternative splicing: named isoforms=4 Note: uncertain whether Met-1 or Met-12 is the initiator

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 280 aa MW = 32 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Thr phosphorylation site {T48} glutamine-rich region {101-106} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S166}

Database Correlations

OMIM 602595 UniProt O14893 Pfam PF04938 Entrez Gene 8487 Kegg hsa:8487

References

UniProt :accession O14893