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suramin
Indications:
- Trypanosoma brucei gambiense & rhodesiense, Stage I (normal CSF)
Dosage:
1) 100-200 mg IV test dose to detect hypersensitivity
2) adults: 1 g IV on days 1,3,7,14 & 21
3) children: 20 mg/kg/day (max 1 g) IV on days 1,3,7,14 & 21
4) slow IV infusion of freshly prepared 10% aqueous solution
Contraindications: patients with renal insufficiency
Pharmacokinetics:
- does not penetrate blood-brain barrier
Adverse effects:
1) transient proteinuria is common
2) renal failure
3) fever
4) photophobia
5) pruritus
6) arthralgias
7) skin eruptions
8) immediate, severe, potentially fatal hypersensitivity reaction (1 in 20,000)
a) nausea/vomiting
b) shock
c) seizures
Monitor:
1) urinalysis
2) discontinue if proteinuria or RBC in urine
Interactions
drug interactions
General
amide
antiprotozoal agent
pharmaceutical angiogenesis inhibitor (angiostatic agent)
sulfonic acid
Database Correlations
PUBCHEM correlations
References
- Goodman and Gilman's The Pharmacological Basis of
Therapeutics, 8th ed. Gilman et al, eds.
Permagon Press/McGraw Hill, 1990. pg 1014-6
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, 1195-96