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tumor suppressor gene or anti-oncogene
Tumor suppressor genes are involved in cell cycle checkpoints. Inactivation of tumor suppressor genes usually occurs by loss of one allele followed by a point mutation in the remaining allele. Homozygous deletions are rare.
Related
anti-oncoprotein (tumor suppressor protein)
Specific
CDKN2C gene
CYLD1 (cylindromatosis) gene
Deleted in Colon Carcinoma [DCC] tumor suppressor gene
deleted in neuroblastoma 5
drosophila discs large [dlg] gene
familial adenomatous polyposis [FAP] gene
KCNRG gene
malignant transformation suppression-1 (MTS1) gene; suppressor of anchorage independence-1 gene; transformation suppressor-1 (TFS-1) gene
MMAC1 or PTEN gene
multiple tumor suppressor-1 (MTS1); INK4; CDKN2A gene
multiple tumor suppressor-2 (MTS2) gene; CDKN2B
Mutated in Colon Carcinoma [MCC] tumor suppressor gene
neurofibromatosis type-1 gene or NF1 gene
neurofibromatosis type-2 gene or NF2 gene
p53 gene
p63 gene
p73 gene
ras GAP gene
retinoblastoma [Rb] gene (Rb1)
SAS gene
WAF1 gene, PIC1, CIP1, SDI1
Wilms tumor gene, WAGR gene or wt1
General
gene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: anti-oncoprotein
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
References
- Cordon-Cardo C.
Mutations of cell cycle regulators. Biological and clinical
implications for human neoplasia.
Am J Pathol. 1995 Sep;147(3):545-60. Review.
PMID: 7677168