suppression of tumorigenicity protein 18 (zinc finger protein 387, ST18, KIAA0535, ZNF387)

Function: 1) transcriptional repressor that binds to DNA sequences containing a bipartite element direct repeat of 5'-AAAGTTT-3' separated by 2-9 nucleotides. 2) represses basal transcription activity from target promoters 3) inhibits colony formation in cultured breast cancer cells Compartment: nucleus Expression: - expressed at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary, prostate > mammary epithelial cells, breast cancer cells

General

transcriptional silencer (transcriptional repressor) zinc finger protein

Properties

SIZE: MW = 115 kD entity length = 1047 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2HC-type SITE: 365-395 EFFECTOR-BOUND: Zn+2 Zn finger C2HC-type SITE: 409-439 EFFECTOR-BOUND: Zn+2 Zn finger C2HC-type SITE: 721-751 EFFECTOR-BOUND: Zn+2 Zn finger C2HC-type SITE: 765-795 EFFECTOR-BOUND: Zn+2 Zn finger C2HC-type SITE: 813-843 EFFECTOR-BOUND: Zn+2 Zn finger C2HC-type SITE: 866-896 EFFECTOR-BOUND: Zn+2 coiled coil {920-992}

Database Correlations

UniProt O60284 PFAM correlations

References

UniProt :accession O60284