probable G-protein coupled receptor 173; super conserved receptor expressed in brain 3 (GPR173, SREB3)

Function: orphan receptor Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - expressed at high levels in brain & ovary - lower levels in small intestine - in brain regions, detected in all regions tested - highest levels in the cerebellum & cerebral cortex

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 41 kD entity length = 373 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-26} MOTIF: N-glycosylation site {N3} transmembrane domain {27-47} cytoplasmic loop {48-59} transmembrane domain {60-80} exoplasmic loop {81-97} MOTIF: cysteine residue {C96} MODIFICATION: cysteine residue {C174} transmembrane domain {98-118} cytoplasmic loop {119-139} transmembrane domain {140-160} exoplasmic loop {161-188} MOTIF: cysteine residue {C174} MODIFICATION: cysteine residue {C96} N-glycosylation site {N184} transmembrane domain {189-209} cytoplasmic loop {210-287} transmembrane domain {288-308} exoplasmic loop {309-322} transmembrane domain {323-343} cytoplasmic domain {344-373}

Database Correlations

OMIM 300253 UniProt Q9NS66 Pfam PF00001 Kegg hsa:5432

References

UniProt :accession Q9NS66