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superwarfarin; rat poison

Indications: - used as rat poison Pharmacokinetics: - 1/2life longer than that of warfarin Laboratory: - high prothrombin time & international normalized ratio (INR) - deficiency in vitamin K-dependent coagulation factors - factor II, factor VII, factor IX, factor X Mechanism of action: - high-potency vitamin K antagonist Management: - fresh frozen plasma & vitamin K - several month of tapering vitamin K therapy may be needed

Related

warfarin (Coumadin, Panwarfin, Jantoven)

General

toxin (hazardous material, poison)

References

  1. NEJM Knowledge+ Hematology
  2. Spahr JE, Maul JS, Rodgers GM. Superwarfarin poisoning: a report of two cases and review of the literature. Am J Hematol. 2007 Jul;82(7):656-60. PMID: 17022046 Free article. Review.
  3. NEJM Knowledge+