supervillin (archvillin, p205/p250, SVIL)

Function: 1) forms high-affinity link between actin cytoskeleton & plasma membrane. 2) isoform 2 (archvillin) is among the first costameric proteins to assemble during myogenesis; it contributes to myogenic membrane structure & differentiation 3) binds to F-actin Structure: 1) belongs to the villin/gelsolin family 2) contains 5 gelsolin-like repeats 3) contains 1 HP domain (headpiece domain) Compartment: - cell membrane, cytoplasmic side - tightly associated with both actin filaments & plasma membrane Alternative splicing: named isoforms=2 Expression: - expressed in many tissues - most abundant in muscle, bone marrow, thyroid, & salivary gland - isoform 2 (archvillin) is muscle specific

General

cytoskeletal protein phosphoprotein

Properties

SIZE: MW = 248 kD entity length = 2214 aa COMPARTMENT: cytoplasm MOTIF: Thr phosphorylation site {T852} Gelsolin-like {1441-1540} Gelsolin-like {1560-1682} Gelsolin-like {1752-1862} Gelsolin-like {1881-1982} Gelsolin-like {2015-2122} HP {2151-2214}

Database Correlations

OMIM 604126 UniProt O95425 PFAM correlations

References

UniProt :accession O95425