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sulfhydryl oxidase 2; neuroblastoma-derived sulfhydryl oxidase; quiescin Q6-like protein 1 (QSOX2, QSCN6L1, SOXN)
Function:
1) catalyzes the oxidation of sulfhydryl groups in peptide & protein thiols to disulfides with reduction of O2 to H2O2
2) disulfide bond formation in a variety of secreted proteins
3) regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis
Cofactor: binds 1 FAD per subunit
Structure:
- monomer
- belongs to the quiescin-sulfhydryl oxidase (QSOX) family
- contains 1 ERV/ALR sulfhydryl oxidase domain
- contains 1 thioredoxin domain
Compartment:
- membrane, secreted
- seems to be predominantly targeted to the nuclear membrane & outer plasma membrane
Expression:
- expressed in pancreas, brain, placenta, kidney, heart, fetal tissues > lung, liver, skeletal muscle
General
flavoprotein
glycoprotein
membrane protein
oxidoreductase
phosphoprotein
Properties
SIZE: entity length = 698 aa
MW = 78 kD
COMPARTMENT: cell nucleus
MOTIF: signal sequence {1-21}
thioredoxin domain
SITE: 34-178
MOTIF: cysteine residue {C91}
MODIFICATION: cysteine residue {C94}
alanine-rich region {41-44}
MOTIF: alanine residue (SEVERAL)
N-glycosylation site {N77}
cysteine residue {C91}
cysteine residue {C94}
cysteine residue {C94}
MODIFICATION: cysteine residue {C91}
N-glycosylation site {N178}
N-glycosylation site {N218}
N-glycosylation site {N266}
cysteine residue {C418}
MODIFICATION: cysteine residue {C430}
ERV/ALR sulfhydryl oxidase {421-530}
MOTIF: binding site
SITE: 426-426
FOR-BINDING-OF: FAD
cysteine residue {C430}
MODIFICATION: cysteine residue {C418}
binding site
SITE: 433-433
FOR-BINDING-OF: FAD
binding site
SITE: 437-437
FOR-BINDING-OF: FAD
cysteine residue {C476}
MODIFICATION: cysteine residue {C479}
binding site
SITE: 478-478
FOR-BINDING-OF: FAD
cysteine residue {C479}
MODIFICATION: cysteine residue {C476}
binding site
SITE: 482-482
FOR-BINDING-OF: FAD
cofactor-binding site [505-512]
COFACTOR-BOUND: flavin adenine dinucleotide
binding site
SITE: 527-527
FOR-BINDING-OF: FAD
binding site
SITE: 530-530
FOR-BINDING-OF: FAD
cysteine residue {C536}
MODIFICATION: cysteine residue {C539}
cysteine residue {C539}
MODIFICATION: cysteine residue {C536}
Ser phosphorylation site {S578}
glutamate-rich region {588-591}
MOTIF: glutamate residue (SEVERAL)
transmembrane domain {662-682}
Database Correlations
OMIM 612860
UniProt Q6ZRP7
PFAM correlations
Entrez Gene 169714
Kegg hsa:169714
ENZYME 1.8.3.2
References
UniProt :accession Q6ZRP7