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sulfate transporter; diastrophic dysplasia protein; solute carrier family 26 member 2 (SLC26A2, DTD, DTDST)
Function:
- sulfate transporter
- may play a role in endochondral bone formation
Structure:
- belongs to the SLC26A/sulP transporter (TC 2.A.53) family
- contains 1 STAS domain
Compartment: membrane
Expression: ubiquitously expressed
Pathology:
- defects in SLC26A2 are the cause of
a) diastrophic dysplasia
b) achondrogenesis type 1B
c) atelosteogenesis type 2
d) multiple epiphyseal dysplasia type 4
Related
diastrophic dysplasia
DTDST gene
General
glycoprotein
phosphoprotein
solute carrier family 26 (SLC26, SLC26A)
transmembrane 12 protein
Properties
SIZE: entity length = 739 aa
MW = 82 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-111}
MOTIF: Ser phosphorylation site {S12}
Ser phosphorylation site {S16}
transmembrane domain {112-132}
exoplasmic loop {133-136}
transmembrane domain {137-157}
cytoplasmic loop {158-159}
transmembrane domain {160-180}
exoplasmic loop {181-218}
MOTIF: N-glycosylation site {N199}
N-glycosylation site {N205}
transmembrane domain {219-239}
cytoplasmic loop {240-241}
transmembrane domain {242-262}
exoplasmic loop {263-296}
transmembrane domain {297-317}
cytoplasmic loop {318-328}
transmembrane domain {329-349}
exoplasmic loop {350-377}
MOTIF: N-glycosylation site {N357}
transmembrane domain {378-398}
cytoplasmic loop {399-420}
transmembrane domain {421-441}
exoplasmic loop {442-454}
transmembrane domain {455-475}
cytoplasmic loop {476-523}
transmembrane domain {524-544}
exoplasmic loop {545-643}
STAS {568-719}
MOTIF: transmembrane domain {644-664}
cytoplasmic domain {665-739}
Database Correlations
OMIM correlations
MORBIDMAP 606718
UniProt P50443
PFAM correlations
Kegg hsa:1836
References
- UniProt :accession P50443
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC26A2
- Hastbacka J et al
The diastrophic dysplasia gene encodes a novel sulfate
transporter: positional cloning by fine-structure linkage
disequilibrium mapping.
Cell 78:1073-87 1994
PMID: 7923357