sulfatase-modifying factor 2 (C-alpha-formyglycine-generating enzyme 2, SUMF2)

Function: 1) unlike SUMF1 a) lacks formyl-glycine generating activity b) unable to convert newly synthesized inactive sulfatases to their active form by modifying an active site Cys to 3-oxoalanine 2) overexpression of SUMF2 inhibits activation of sulfatases by SUMF1 Compartment: endoplasmic reticulum lumen Alternative splicing: named isoforms=4 Expression: - detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

General

Ca+2 binding protein glycoprotein

Properties

SIZE: MW = 34 kD entity length = 301 aa COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-25} cysteine residue {C156} MODIFICATION: cysteine residue {C290} N-glycosylation site {N191} Ca+2-binding site SITE: 194-194 Ca+2-binding site SITE: 195-195 Ca+2-binding site SITE: 208-208 Ca+2-binding site SITE: 210-210 Ca+2-binding site SITE: 229-229 Ca+2-binding site SITE: 232-232 Ca+2-binding site SITE: 234-234 Ca+2-binding site SITE: 236-236 cysteine residue {C290} MODIFICATION: cysteine residue {C156}

Database Correlations

OMIM 607940 UniProt Q8NBJ7 Pfam PF03781

References

UniProt :accession Q8NBJ7