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substance-P receptor; SPR; NK-1 receptor; NK-1R; Tachykinin receptor 1 (TACR1, NK1R, TAC1R)
Function:
- receptor for the tachykinin neuropeptide substance P
- probably associated with G proteins that activate phosphatidylinositol-Ca+2 second messenger system
- rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Interactions
molecular events
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 407 aa
MW = 46 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-31}
MOTIF: N-glycosylation site {N14}
N-glycosylation site {N18}
transmembrane domain {32-54}
cytoplasmic loop {55-64}
transmembrane domain {65-86}
exoplasmic loop {87-106}
MOTIF: cysteine residue {C105}
MODIFICATION: cysteine residue {C180}
transmembrane domain {107-128}
cytoplasmic loop {129-148}
transmembrane domain {149-169}
exoplasmic loop {170-194}
MOTIF: cysteine residue {C180}
MODIFICATION: cysteine residue {C105}
transmembrane domain {195-219}
MOTIF: binding site
SITE: 197-197
FOR-BINDING-OF: CP 96345
cytoplasmic loop {220-248}
transmembrane domain {249-270}
exoplasmic loop {271-283}
transmembrane domain {284-308}
cytoplasmic domain {309-407}
MOTIF: cysteine residue {C322}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 162323
UniProt P25103
Pfam PF00001
Kegg hsa:6869
References
- UniProt :accession P25103
- Wikipedia; Note: Tachykinin entry
http://en.wikipedia.org/wiki/Tachykinin
- Gerard NP, Eddy RL Jr, Shows TB, Gerard C.
The human neurokinin A (substance K) receptor. Molecular
cloning of the gene, chromosome localization, and isolation of
cDNA from tracheal and gastric tissues.
J Biol Chem. 1990 Nov 25;265(33):20455-62.
Erratum in: J Biol Chem. 1991 Jan 15;266(2):1354.
PMID: 2173708
- Fong TM, Cascieri MA, Yu H, Bansal A, Swain C, Strader CD.
Amino-aromatic interaction between histidine 197 of the
neurokinin-1 receptor and CP 96345.
Nature. 1993 Mar 25;362(6418):350-3.
PMID: 8384323
- Elling CE, Nielsen SM, Schwartz TW.
Conversion of antagonist-binding site to metal-ion site in the
tachykinin NK-1 receptor.
Nature. 1995 Mar 2;374(6517):74-7.
PMID: 7532789