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substance-K receptor; SKR; neurokinin A receptor; NK-2 receptor; NK-2R; tachykinin receptor 2 (TACR2, NK2R, NKNAR, TAC2R)
Function:
- receptor for the tachykinin neuropeptide substance K (neurokinin A)
- associated with G proteins that activate phosphatidylinositol-Ca+2 second messenger system
- affinity to tachykinins is: substance K > neuromedin-K > substance P
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 398 aa
MW = 44 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-32}
MOTIF: N-glycosylation site {N11}
N-glycosylation site {N19}
transmembrane domain {33-56}
cytoplasmic loop {57-69}
transmembrane domain {70-90}
exoplasmic loop {91-107}
MOTIF: cysteine residue {C106}
MODIFICATION: cysteine residue {C181}
transmembrane domain {108-129}
cytoplasmic loop {130-149}
transmembrane domain {150-170}
exoplasmic loop {171-196}
MOTIF: cysteine residue {C181}
MODIFICATION: cysteine residue {C106}
transmembrane domain {197-218}
cytoplasmic loop {219-251}
transmembrane domain {252-272}
exoplasmic loop {273-290}
transmembrane domain {291-310}
cytoplasmic domain {311-398}
MOTIF: cysteine residue {C324}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 162321
UniProt P21452
Pfam PF00001
References
UniProt :accession P21452