Contents

Search

sublingual immunotherapy (SLIT)

Indications: - treatment of allergic rhinoconjunctivitis in children & adults - prophylaxis for allergic rhinitis & asthma exacerbations due to dust mite allergy* [4] * no effect on quality of life [4] Procedure: - sublingual allergen extract used to desensitize allergic reaction - Grastek: sublingual tablet for treating Timothy grass pollen allergy - Oralair: sublingual tablet for treating grass pollen allergy - Ragwitek: sublingual tablet for treating short ragweed pollen allergy - 2 years of sublingual immunotherapy for grass pollen allergy insufficient for long-term benefits [5] Mechanism of action: - Oralair contains extracts from five grass pollens: - Kentucky bluegrass, orchardgrass, perennial ryegrass, sweet vernal grass, & Timothy grass [3] - Grastek contains timothy grass extract - Ragwitek contains ragweed pollen extract

Related

sublingual allergen extract

General

antigen desensitization; allergen immunotherapy

References

  1. Frew AJ. Sublingual immunotherapy. N Engl J Med. 2008 May 22;358(21):2259-64. Review. PMID: 18499568
  2. Wahn U et al Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis. J Allergy Clin Immunol 2009 Jan; 123:160 PMID: 19046761 - Bufe A et al Safety and efficacy in children of an SQ-standardized grass allergen table for sublingual immunotherapy. J Allergy Clin Immunol 2009 Jan; 123:167. PMID: 1913093
  3. Physician's First Watch, December 16, 2013 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - Durham SR et al. Long-term clinical efficacy in grass pollen- induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet. J Allergy Clin Immunol 2010 Jan; 125:131 PMID: 20109743 - Didier A et al. Sustained 3-year efficacy of pre- and coseasonal 5-grass- pollen sublingual immunotherapy tablets in patients with grass pollen-induced rhinoconjunctivitis. J Allergy Clin Immunol 2011 Sep; 128:559. PMID: 21802126
  4. Virchow JC, Backer V, Kuna P et al Efficacy of a House Dust Mite Sublingual Allergen Immunotherapy Tablet in Adults With Allergic Asthma. A Randomized Clinical Trial. JAMA. 2016;315(16):1715-1725 PMID: 27115376 http://jama.jamanetwork.com/article.aspx?articleid=2516714 - Wood RA New Horizons in Allergen Immunotherapy. JAMA. 2016 Apr 26;315(16):1711-1712. PMID: 27115374 http://jama.jamanetwork.com/article.aspx?articleid=2516688
  5. Scadding GW, Calderon MA, Shamji MH et al Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial. JAMA. 2017 Feb 14;317(6):615-625. PMID: 28196255 http://jamanetwork.com/journals/jama/article-abstract/2601501 - Cox LS. Sublingual Immunotherapy for Allergic Rhinitis: Is 2-Year Treatment Sufficient for Long-term Benefit? JAMA. 2017 Feb 14;317(6):591-593. PMID: 28196239 http://jamanetwork.com/journals/jama/article-abstract/2601485
  6. Canonica GW, Cox L, Pawankar R et al Sublingual immunotherapy: World Allergy Organization position paper 2013 update. World Allergy Organ J. 2014 Mar 28;7(1):6. PMID: 24679069 Free PMC Article https://waojournal.biomedcentral.com/articles/10.1186/1939-4551-7-6