structural maintenance of chromosome 1-like 2 protein; SMC1beta protein (SMC1L2, SMC1B)

Function: 1) meiosis-specific component of cohesin complex - alternate for SMC1L1 2) contributes to axial element formation & the organization of chromatin loops along the axial element 3) role in synapsis, recombination & chromosome movements 4) forms a heterodimer with SMC3 Structure: - flexible hinge domain - separates the large intramolecular coiled coil regions - allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer - the 2 heads of the heterodimer are then connected by different ends of the cleavable RAD21 or REC8 protein, forming a ring structure - belongs to the SMC family. SMC1 subfamily Compartment: nucleus, associates with chromatin

General

nuclear protein protein subunit

Properties

SIZE: MW = 144 kD entity length = 1235 aa COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 32-39 coiled coil {156-490} coiled coil {666-934} coiled coil {970-994} coiled coil {1022-1049}

Database Correlations

OMIM 608685 UniProt Q8NDV3 PFAM correlations

References

UniProt :accession Q8NDV3